UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P04629
Entry Name

NTRK1_HUMAN
Protein Name

High affinity nerve growth factor receptor
Primary Gene Name

NTRK1
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name NTRK1 (TrkA)
Cell Type (CHO) cells
Substrate Description NGFR signaling neuron cell proliferation, differentiation and survival
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor receptor (NGFR)
Sheddase ADAM17
Shedding-related Disease growth factor receptor (NGFR)
Short Summary of Papers extracellular signal-regulated kinase (Erk) regulated the cleavage of TrkA
Cleavage Information NONE
PMID 12058067



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		33 423
Transmembrane
 		424 439



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 12058067   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
HCSD cancer(Lung adenocarcinoma) 22985211