UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P04626
Entry Name

ERBB2_HUMAN
Protein Name

Receptor tyrosine-protein kinase erbB-2
Primary Gene Name

ERBB2
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Transferase
Kinase
Activator
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name ERBB2 (HER2)
Cell Type breast cancer cells
Substrate Description ECD-HER2 as breast cancer surrogate marker
Substrate Function Category disease;growth factor & growth hormone
Substrate Function Subtype growth factor receptor (ERBBs); Disease: Cancers (breast)
Sheddase ADAM10
Shedding-related Disease cancer (breast); growth factor receptor(ERBBs)
Short Summary of Papers HER2 extracellular domain shedding result in a fragment with constitutive kinase activity, provide ligand-independent growth and survival signals
Cleavage Information NONE
PMID 16627989 21549508



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		23 652
Transmembrane
 		653 675



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TACP*YNYL 300 UNKNOWN Mass spectrometry 33796845   
PAPER GCPA*EQRA 644 unknown (assume metalloproteinase family) carboxyl terminal amino acid sequencing 12767812   
PAPER AEQR*ASPL 647 unknown (assume metalloproteinase family) carboxyl terminal amino acid sequencing 12767812   
MEROPS DMGD*LVDA 1016 caspase-3 physiologically relevant NONE 18420586   
MEROPS DMGD*LVDA 1016 caspase-8 physiologically relevant NONE 18420586   
PMAP DMGD*LVDA 1016 caspase-6 This entry is a predicted Gel electrophoresis 18420586   
PMAP DMGD*LVDA 1016 caspase-7 This entry is a predicted Gel electrophoresis 18420586   
PMAP DMGD*LVDA 1016 caspase-3 This entry is based on an experiment Mutagenesis 18420586   
PMAP DMGD*LVDA 1016 caspase-8 This entry is based on an experiment Mutagenesis 18420586   
MEROPS DLVD*AEEY 1019 caspase-3 physiologically relevant NONE 18420586   
MEROPS DLVD*AEEY 1019 caspase-8 physiologically relevant NONE 18420586   
PMAP DLVD*AEEY 1019 caspase-6 This entry is a predicted Gel electrophoresis 18420586   
PMAP DLVD*AEEY 1019 caspase-7 This entry is a predicted Gel electrophoresis 18420586   
PMAP DLVD*AEEY 1019 caspase-3 This entry is based on an experiment Mutagenesis 18420586   
PMAP DLVD*AEEY 1019 caspase-8 This entry is based on an experiment Mutagenesis 18420586   
MEROPS DVFD*GDLG 1087 caspase-3 physiologically relevant NONE 18420586   
MEROPS DVFD*GDLG 1087 caspase-8 physiologically relevant NONE 18420586   
PMAP DVFD*GDLG 1087 caspase-6 This entry is a predicted Gel electrophoresis 18420586   
PMAP DVFD*GDLG 1087 caspase-7 This entry is a predicted Gel electrophoresis 18420586   
PMAP DVFD*GDLG 1087 caspase-3 This entry is based on an experiment Mutagenesis 18420586   
PMAP DVFD*GDLG 1087 caspase-8 This entry is based on an experiment Mutagenesis 18420586   
MEROPS SETD*GYVA 1125 caspase-3 physiologically relevant NONE 18420586   
MEROPS SETD*GYVA 1125 caspase-8 physiologically relevant NONE 18420586   
PMAP SETD*GYVA 1125 caspase-6 This entry is a predicted Gel electrophoresis 18420586   
PMAP SETD*GYVA 1125 caspase-7 This entry is a predicted Gel electrophoresis 18420586   
PMAP SETD*GYVA 1125 caspase-3 This entry is based on an experiment Mutagenesis 18420586   
PMAP SETD*GYVA 1125 caspase-8 This entry is based on an experiment Mutagenesis 18420586   
PAPER YVAP*LTCS 1130 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM10 16627989   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16739989
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer (gastric cancer) 23161554
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(breast cancer) 24505115
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452