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| UniProt ID |
P04439 |
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| Entry Name |
HLAA_HUMAN |
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| Protein Name |
HLA class I histocompatibility antigen, A alpha chain |
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| Primary Gene Name |
HLA-A |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | HLA (human leucocyte antigen)-A2 | |
| Cell Type | ||
| Substrate Description | T-cell development; immune cell responses | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; surface antigen | |
| Sheddase | ADAM10, | |
| Shedding-related Disease | cell surface protein | |
| Short Summary of Papers | the MHC I protein HLA-A2 undergo extra-cellular domain cleavage mediated by α-secretases and the cleavage product is subsequently cleaved by PS1/γ-secretase | |
| Cleavage Information | NONE | |
| PMID | 17150042 |
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Start | End |
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25 | 308 |
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309 | 332 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | QTWA*GSHS | 24 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 92029 | ||
| PMAP | AVIT*GAVV | 323 | presenilin 1 | This entry is a predicted | Others | 17150042 18942891 | ||
| PMAP | VAAV*MWRR | 330 | ADAM10 peptidase | This entry is a predicted | Others | 17150042 | ||
| PMAP | FGAV*ITGA | 321* | presenilin 1 | This entry is a predicted | Others | 17150042 18942891 | ||
| PAPER | No_information | ADAM10, | HLA (human leucocyte antigen)-A2 | |||||