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|---|---|---|
| UniProt ID |
P04233 |
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| Entry Name |
HG2A_HUMAN |
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| Protein Name |
HLA class II histocompatibility antigen gamma chain |
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| Primary Gene Name |
CD74 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Chaperone |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | HLA-DR (CD74) | |
| Cell Type | ||
| Substrate Description | cell surface receptor for the cytokine MIF. plays a critical role in MHC class II antigen processing. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | CD74 is subject to RIP (regulated intramembrane proteolysis) after ectodomain shedding, and the cytoplasmic domains are then transported to the cell nucleus and induces activation of transcription mediated by the NF-kappaB p65/RelA homodimer and the B-cell-enriched coactivator, TAF(II)105 | |
| Cleavage Information | NONE | |
| PMID | 16107560 |
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Start | End |
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47 | 72 |
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73 | 296 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ISNN*EQLP | 27 | legumain, animal-type | physiologically relevant | N-terminal sequencing | 12705852 | ||
| MEROPS | QLEN*LRMK | 92 | legumain, animal-type | physiologically relevant | N-terminal sequencing | 12705852 | ||
| MEROPS | HLKN*TMET | 171 | legumain, animal-type | physiologically relevant | N-terminal sequencing | 12705852 | ||
| PMAP | No_information | I-CLiP | This entry is based on an experiment | Gel electrophoresis | 16107560 | |||