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| UniProt ID |
P04216 |
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| Entry Name |
THY1_HUMAN |
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| Protein Name |
Thy-1 membrane glycoprotein |
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| Primary Gene Name |
THY1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | Thy-1 | |
| Cell Type | ||
| Substrate Description | involved in T cell activation, leukocyte and melanoma cell adhesion and migration. inhibition of neurite outgrowth. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | phospholipase | |
| Shedding-related Disease | cell surface protein | |
| Short Summary of Papers | Thy-1 is released to human cerebrospinal fluid (CSF) from membranes of the central nervous system by a phospholipase; inflammatory and fibrogenic cytokines and growth factors down-regulate Thy-1 expression in normal human lung and skin fibroblasts in vitro, with accumulation of soluble Thy-1 in conditioned media suggesting shedding of cell-surface Thy-1. | |
| Cleavage Information | GPI-anchor | |
| PMID | 77877 2900838 16049324 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | phospholipase | 77877 2900838 16049324 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |