|
|
||
|---|---|---|
| UniProt ID |
P04156 |
|
| Entry Name |
PRIO_HUMAN |
|
| Protein Name |
Major prion protein |
|
| Primary Gene Name |
PRNP |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Prion |
|
| Membrane Location |
Cell membrane |
|
|
|
|---|
| Substrate Name | PrPc | |
| Cell Type | HEK293 cells | |
| Substrate Description | neuroprotective | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Central nervous system (CNS) pathology; Disease (Creutzfeldt-Jakob disease) | |
| Sheddase | ADAM8, ADAM10, ADAM17 | |
| Shedding-related Disease | Creutzfeldt-Jakob disease | |
| Short Summary of Papers | α-cleavage of PrPC, produces functionally significant N1 and C1 fragments and disrupts a region critical for both prion replication and PrP toxicity. | |
| Cleavage Information | GPI-anchor | |
| PMID | 11477090 18951988 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
||
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LCKK*RPKP | 24 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| HPRD | GGTH*SQWN | 96 | 15050367 11060296 | |||||
| HPRD | GGTH*SQWN | 96 | 15050367 11060296 | |||||
| HPRD | NMKH*MAGA | 111 | 15050367 7642585 | |||||
| HPRD | NMKH*MAGA | 111 | 15050367 7642585 | |||||
| MEROPS | NMKH*MAGA | 111 | ADAM10 peptidase | not physiologically relevant | NONE | 16263114 | ||
| MEROPS | NMKH*MAGA | 111 | ADAM17 peptidase | not physiologically relevant | NONE | 17428986 | ||
| PMAP | NMKH*MAGA | 111 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 17428986 | ||
| PMAP | NMKH*MAGA | 111 | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | 16263114 | |||
| PAPER | HMAG*AAAA | 114 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AGAA*AAGA | 116 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GAAA*AGAV | 117 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AAAG*AVVG | 119 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AAGA*VVGG | 120 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | GSAM*SRPI | 134 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | KGEN*FTET | 197 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | MMER*VVEQ | 208 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM8, ADAM10, ADAM17 | N-terminal sequencing | 11477090 23052041 | ||||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 25216327 | |