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| UniProt ID |
P04083 |
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| Entry Name |
ANXA1_HUMAN |
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| Protein Name |
Annexin A1 |
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| Primary Gene Name |
ANXA1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Phospholipase A2 inhibitor |
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| Membrane Location |
Secreted |
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| Substrate Name | Annexin 1 | |
| Cell Type | ||
| Substrate Description | innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. anti-inflammatory activity | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | elastase | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | Annexin 1 N-terminal domain, cleaved and released by human leukocyte elastase, participate in the recruitment and activation of leukocytes at sites of inflammation. | |
| Cleavage Information | NONE | |
| PMID | 17023068 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | M*AMVS | 1 | unknown peptidase | physiologically relevant | Mass spectroscopy | 16739993 | ||
| MEROPS | DVAA*LHKA | 50 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | KAIM*VKGV | 56 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | KGVD*EATI | 61 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | KGVD*EATI | 61 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | KGVD*EATI | 61 | LAST_MAM peptidase (Limulus-type) | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | GVDE*ATII | 62 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VDEA*TIID | 63 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ILTK*RNNA | 71 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LTKR*NNAQ | 72 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LRAA*MKGL | 126 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | LRAA*MKGL | 126 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | AAMK*GLGT | 128 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | TDED*TLIE | 135 | unknown peptidase | physiologically relevant | Mass spectroscopy | 16179924 | ||
| MEROPS | LASR*TNKE | 144 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DLAK*DITS | 166 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GDFR*NALL | 177 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | FRNA*LLSL | 179 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | SLAK*GDRS | 185 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | KGDR*SEDF | 188 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DRSE*DFGV | 190 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | SDAR*ALYE | 204 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DMNK*VLDL | 250 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LELK*GDIE | 257 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | KMYG*ISLC | 320 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | GISL*CQAI | 323 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DYEK*ILVA | 337 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | No_information | elastase | 17023068 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |