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| UniProt ID |
P02786 |
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| Entry Name |
TFR1_HUMAN |
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| Protein Name |
Transferrin receptor protein 1 |
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| Primary Gene Name |
TFRC |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
|
| Membrane Location |
Secreted |
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| Substrate Name | transferrin receptor | |
| Cell Type | ||
| Substrate Description | cellular uptake of iron. receptor-mediated endocytosis of transferrin-iron (Tf-Fe). | |
| Substrate Function Category | blood and homoeostasis | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | iron homeostasis | |
| Short Summary of Papers | release of soluble transferrin receptor from the surface via proteolytic cleavage. the soluble Tf receptors retain high affinity to Tf and may inhibit Tf binding to cells. | |
| Cleavage Information | NONE | |
| PMID | 2752136 |
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Start | End |
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68 | 88 |
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89 | 760 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | GTIK*LLNE | 145 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | AFPF*LAYS | 544 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | FLAY*SGIP | 547 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unknown) | 2752136 | |||||
| PAPER | No_information | ADAM17 | 14625290 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 15608170 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(Glioblastoma) | 21601021 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(lung cancer) | 21186846 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |