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|---|---|---|
| UniProt ID |
P01833 |
|
| Entry Name |
PIGR_HUMAN |
|
| Protein Name |
Polymeric immunoglobulin receptor |
|
| Primary Gene Name |
PIGR |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Secreted |
|
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|---|
| Substrate Name | Polymeric Immunoglobulin Receptor | |
| Cell Type | ||
| Substrate Description | polymeric IgA and IgM binding receptor. the binding complex is then transported across the cell to be secreted | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | IFN-r increased the shedding of secretory component (SC), receptor for polymeric immunoglobulins. | |
| Cleavage Information | NONE | |
| PMID | 3108385 |
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|---|---|---|
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Start | End |
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19 | 638 |
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639 | 661 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AIST*KSPI | 18 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 1859628 | ||
| PAPER | LCPY*NRKE | 373 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | LTLN*LVTR | 532 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TLVP*LGLV | 646 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VPLG*LVLA | 648 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unknown) | 3108385 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Milk | 12833513 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Nipple aspiration fluid | 12889602 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16740002 | |
| Sys-BodyFluid | Saliva | 15048992 | |
| Sys-BodyFluid | Saliva | 16402355 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Saliva | 15473691 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Tear | 16335950 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 15048996 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17081049 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Glioblastoma) | 21601021 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(lung cancer) | 21806062 | |