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|---|---|---|
| UniProt ID |
P01732 |
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| Entry Name |
CD8A_HUMAN |
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| Protein Name |
T-cell surface glycoprotein CD8 alpha chain |
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| Primary Gene Name |
CD8A |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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|---|
| Substrate Name | CD8(Leu-2) | |
| Cell Type | ||
| Substrate Description | identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets.play a role in the process of T-cell mediated killing | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cystic fibrosis | |
| Short Summary of Papers | soluble form of Leu-2(CD8) are released in supernatants and serum resulted from proteolytic cleavage of the membrane-bound Leu-2; cleavage of lymphocyte surface antigens CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis. | |
| Cleavage Information | NONE | |
| PMID | 6203997 6193233 7722333 |
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Start | End |
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22 | 182 |
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183 | 203 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | (unknown) | 6203997 6193233 | |||||