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| UniProt ID |
P01730 |
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| Entry Name |
CD4_HUMAN |
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| Protein Name |
T-cell surface glycoprotein CD4 |
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| Primary Gene Name |
CD4 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Cell membrane |
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| Substrate Name | CD4 | |
| Cell Type | ||
| Substrate Description | accessory protein for MHC class-II antigen/T-cell receptor interaction. may regulate T-cell activation. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | elastase, cathepsin G, metalloproteinase | |
| Shedding-related Disease | cystic fibrosis, Rheumatoid Arthritis | |
| Short Summary of Papers | cleavage of lymphocyte surface antigens CD4 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis, may lead to a temporary state of immunologic unresponsiveness in chronic inflammation in CF patients; increased soluble CD4 in serum of Rheumatoid Arthritis Patients by Matrix Metalloproteinase (MMP)-Like Proteinases | |
| Cleavage Information | NONE | |
| PMID | 7722333 23700441 |
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Start | End |
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26 | 396 |
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397 | 418 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ATQG*KKVV | 25 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| MEROPS | VVLG*KKGD | 31 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | TASQ*KKSI | 45 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | No_information | elastase, cathepsin G | 7722333 | |||||
| PAPER | No_information | metallopeptidase | 23700441 | |||||