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| UniProt ID |
P01375 |
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| Entry Name |
TNFA_HUMAN |
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| Protein Name |
Tumor necrosis factor |
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| Primary Gene Name |
TNF |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | TNF-α | |
| Cell Type | endothelial cell, monocytes, lymphocytes, neutrophils | |
| Substrate Description | Leukocyte Recruitment, Chemokine recruitment of leukocytes | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM17, MMP-7 PR3(proteinase 3) | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | generate soluble TNF antagonist whichdown-regulate mTNF signaling | |
| Cleavage Information | NONE | |
| PMID | 16565325 |
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Start | End |
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36 | 56 |
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57 | 233 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LFLS*LFSF | 34 | signal peptide peptidase-like protein 2B | physiologically relevant | NONE | 16829951 | ||
| MEROPS | LFLS*LFSF | 34 | signal peptide peptidase-like protein 2A | physiologically relevant | NONE | 19189970 | ||
| MEROPS | LSLF*SFLI | 36 | signal peptide peptidase-like protein 2B | physiologically relevant | NONE | 19189970 | ||
| MEROPS | LSLF*SFLI | 36 | signal peptide peptidase-like protein 2A | physiologically relevant | NONE | 19189970 | ||
| MEROPS | FSFL*IVAG | 39 | signal peptide peptidase-like protein 2B | physiologically relevant | NONE | 16829951 | ||
| MEROPS | FSFL*IVAG | 39 | signal peptide peptidase-like protein 2A | physiologically relevant | NONE | 19189970 | ||
| MEROPS | TLFC*LLHF | 49 | signal peptide peptidase-like protein 2B | physiologically relevant | NONE | 16829951 | ||
| MEROPS | TLFC*LLHF | 49 | signal peptide peptidase-like protein 2A | physiologically relevant | NONE | 19189970 | ||
| MEROPS | FCLL*HFGV | 51 | signal peptide peptidase-like protein 2B | physiologically relevant | NONE | 16829951 | ||
| MEROPS | FCLL*HFGV | 51 | signal peptide peptidase-like protein 2A | physiologically relevant | NONE | 19189970 | ||
| MEROPS | DLSL*ISPL | 69 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 15118097 | ||
| PMAP | DLSL*ISPL | 69 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Mass spectrometry | 15118097 | ||
| MEROPS | LISP*LAQA | 72 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 15118097 | ||
| PMAP | LISP*LAQA | 72 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Mass spectrometry | 15118097 | ||
| HPRD | SPLA*QAVR | 74 | ADAM 17; Matrix metalloproteinase 17; ADAM metallopeptidase domain 9; | 10799478 9920899 | ||||
| MEROPS | SPLA*QAVR | 74 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 15118097 | ||
| MEROPS | SPLA*QAVR | 74 | ADAM8 peptidase | physiologically relevant | NONE | 12135759 | ||
| MEROPS | SPLA*QAVR | 74 | ADAM9 peptidase | physiologically relevant | NONE | 12135759 | ||
| PMAP | SPLA*QAVR | 74 | ADAM9 peptidase | This entry is based on an experiment | 12135759 | |||
| PMAP | SPLA*QAVR | 74 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Mass spectrometry | 15118097 | ||
| MEROPS | PLAQ*AVRS | 75 | membrane-type matrix metallopeptidase-4 | physiologically relevant | NONE | 12135759 | ||
| HPRD | LAQA*VRSS | 76 | ADAM metallopeptidase domain 9; ADAM 17; | 9920899 12135369 10799478 | ||||
| MEROPS | LAQA*VRSS | 76 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 15118097 | ||
| MEROPS | LAQA*VRSS | 76 | ADAM8 peptidase | physiologically relevant | NONE | 12135759 | ||
| MEROPS | LAQA*VRSS | 76 | ADAM10 peptidase | physiologically relevant | NONE | 9305925 | ||
| MEROPS | LAQA*VRSS | 76 | ADAM17 peptidase | physiologically relevant | NONE | 12135369 | ||
| PMAP | LAQA*VRSS | 76 | ADAM17 peptidase | This entry is based on an experiment | 12135369 9034190 | |||
| PMAP | LAQA*VRSS | 76 | membrane-type matrix metallopeptidase-4 | This entry is based on an experiment | 10799478 | |||
| PMAP | LAQA*VRSS | 76 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Mass spectrometry | 15118097 | ||
| PMAP | LAQA*VRSS | 76 | ADAM10 peptidase | Others | 9305925 9034190 | |||
| MEROPS | QAVR*SSSR | 78 | gingipain RgpA | not physiologically relevant | NONE | 9506956 | ||
| MEROPS | QAVR*SSSR | 78 | gingipain RgpB | physiologically relevant | NONE | 9506956 | ||
| MEROPS | QAVR*SSSR | 78 | ADAM19 peptidase | physiologically relevant | NONE | 12682046 | ||
| PMAP | QAVR*SSSR | 78 | gingipain R1 | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| PMAP | QAVR*SSSR | 78 | gingipain R2 | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| PMAP | QAVR*SSSR | 78 | adamalysin-19 | This entry is based on an experiment | Mass spectrometry | 12682046 | ||
| HPRD | AVRS*SSRT | 79 | ADAM metallopeptidase domain 9 | 9920899 | ||||
| MEROPS | AVRS*SSRT | 79 | ADAM9 peptidase | physiologically relevant | NONE | 12135759 | ||
| MEROPS | AVRS*SSRT | 79 | ADAM19 peptidase | physiologically relevant | NONE | 12682046 | ||
| PMAP | AVRS*SSRT | 79 | adamalysin-19 | This entry is based on an experiment | Mass spectrometry | 12682046 | ||
| PMAP | AVRS*SSRT | 79 | ADAM9 peptidase | This entry is based on an experiment | 12135759 | |||
| MEROPS | SSSR*TPSD | 82 | gingipain RgpA | not physiologically relevant | NONE | 9506956 | ||
| MEROPS | SSSR*TPSD | 82 | gingipain RgpB | physiologically relevant | NONE | 9506956 | ||
| PMAP | SSSR*TPSD | 82 | gingipain R1 | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| PMAP | SSSR*TPSD | 82 | gingipain R2 | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| MEROPS | LNRR*ANAL | 108 | gingipain RgpB | physiologically relevant | NONE | 9506956 | ||
| PMAP | LNRR*ANAL | 108 | gingipain R2 | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| MEROPS | VLFK*GQGC | 141 | gingipain Kgp | physiologically relevant | NONE | 9506956 | ||
| PMAP | VLFK*GQGC | 141 | gingipain K | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| MEROPS | YQTK*VNLL | 166 | gingipain Kgp | physiologically relevant | NONE | 9506956 | ||
| PMAP | YQTK*VNLL | 166 | gingipain K | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| MEROPS | SAIK*SPCQ | 174 | gingipain Kgp | physiologically relevant | NONE | 9506956 | ||
| PMAP | SAIK*SPCQ | 174 | gingipain K | This entry is based on an experiment | N-terminal sequencing | 15731048 9506956 | ||
| PMAP | No_information | trepolisin | This entry is based on an experiment | Gel electrophoresis | 16552080 | |||