|
|
||
|---|---|---|
| UniProt ID |
P01135 |
|
| Entry Name |
TGFA_HUMAN |
|
| Protein Name |
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha |
|
| Primary Gene Name |
TGFA |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Mitogen |
|
| Membrane Location |
Secreted |
|
|
|
|---|
| Substrate Name | TGF-α | |
| Cell Type | human colon carcinoma cell | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (colon carcinoma) | |
| Sheddase | unkown | |
| Shedding-related Disease | cancer (colon carcinoma) | |
| Short Summary of Papers | defective shedding of mTGF-α enhanced activation of the EGFR in malignant cells | |
| Cleavage Information | NONE | |
| PMID | 10773880 |
| Substrate Name | TGF-α | |
| Cell Type | human peripheral blood mononuclear cells (hPBMCs) | |
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | shedding derived soluble EGF family growth factors, and transactivation of EGFR | |
| Cleavage Information | NONE | |
| PMID | 12590602 |
| Substrate Name | TGF-α | |
| Cell Type | gastric mucosal cells | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: gastric mucosa Infection by H. pylori trigger inflammatory responses | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | gastric mucosa Infection by H. pylori | |
| Short Summary of Papers | H. pylori LPS-induced TGF-α ectodomain shedding and EGFR transactivation | |
| Cleavage Information | NONE | |
| PMID | 26658844 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
24 | 98 |
|
|
99 | 124 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | VAAA*VVSH | 39 | ADAM 17 | 11823465 | ||||
| MEROPS | VAAA*VVSH | 39 | ADAM10 peptidase | physiologically relevant | NONE | 12590602 | ||
| MEROPS | VAAA*VVSH | 39 | ADAM17 peptidase | physiologically relevant | NONE | 12590602 | ||
| PMAP | VAAA*VVSH | 39 | ADAM10 peptidase | This entry is based on an experiment | 12590602 | |||
| PMAP | VAAA*VVSH | 39 | ADAM17 peptidase | This entry is based on an experiment | 12590602 | |||
| MEROPS | CPDS*HTQF | 50 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | SHTQ*FCFH | 53 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | HTQF*CFHG | 54 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | QFCF*HGTC | 56 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | FHGT*CRFL | 59 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | HGTC*RFLV | 60 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | ACVC*HSGY | 73 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | CVCH*SGYV | 74 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| MEROPS | GYVG*ARCE | 79 | insulysin | physiologically relevant | Mass spectroscopy | 19896952 | ||
| HPRD | DLLA*VVAA | 89 | ADAM 17 | 11823465 | ||||
| MEROPS | DLLA*VVAA | 89 | ADAM17 peptidase | physiologically relevant | NONE | 11823465 | ||
| PMAP | DLLA*VVAA | 89 | ADAM17 peptidase | This entry is based on an experiment | 11823465 | |||