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| UniProt ID |
P01133 |
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| Entry Name |
EGF_HUMAN |
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| Protein Name |
Pro-epidermal growth factor |
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| Primary Gene Name |
EGF |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Growth factor |
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| Membrane Location |
Membrane |
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| Substrate Name | EGF | |
| Cell Type | MEF | |
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | soluble agonist of EGFR; activation of EGFR signaling | |
| Cleavage Information | NONE | |
| PMID | 14993236 18951988 |
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Start | End |
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23 | 1032 |
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1033 | 1053 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | YSVR*NSDS | 970 | (unkown) | 8394682 | ||||
| HPRD | WWEL*RHAG | 1022 | Carboxypeptidase M | 7615511 8796265 | ||||
| MEROPS | WWEL*RHAG | 1022 | carboxypeptidase M | physiologically relevant | N-terminal sequencing | 8796265 | ||
| PMAP | WWEL*RHAG | 1022 | carboxypeptidase M | This entry is based on an experiment | 8796265 | |||
| PMAP | WWEL*RHAG | 1022 | carboxypeptidase M | This entry is based on an experiment | 7615511 | |||
| PAPER | WELR*HAGH | 1023 | (unkown) | 8394682 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 16807940 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |