UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P01132
Entry Name

EGF_MOUSE
Protein Name

Pro-epidermal growth factor
Primary Gene Name

Egf
Organism

Mus musculus (Mouse)
Molecular Function

Growth factor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name EGF
Cell Type MEF
Substrate Description EGFR signaling, various signals in cell proliferation, survival and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (EGFR)
Sheddase ADAM10, ADAM17
Shedding-related Disease growth factor (EGFR)
Short Summary of Papers soluble agonist of EGFR; activation of EGFR signaling
Cleavage Information NONE
PMID 14993236 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		29 1038
Transmembrane
 		1039 1058



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS HLDR*NSYP 976 kallikrein 1-related peptidase b9 (Mus musculus) physiologically relevant NONE NONE   
MEROPS WELR*HAGY 1029 kallikrein 1-related peptidase b9 (Mus musculus) physiologically relevant NONE NONE   
PMAP No_information ADAM10 peptidase This_entry_is_based_on_an_experiment. 14993236   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825