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|---|---|---|
| UniProt ID |
P01130 |
|
| Entry Name |
LDLR_HUMAN |
|
| Protein Name |
Low-density lipoprotein receptor |
|
| Primary Gene Name |
LDLR |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Host cell receptor for virus entry |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | Low-density lipoprotein receptor(LDLR) | |
| Cell Type | ||
| Substrate Description | cholesterol-carrying lipoprotein, transports cholesterol into cells by endocytosis | |
| Substrate Function Category | lipid (lipoprotein receptor famiy) | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | LDL receptors is proteolytic cleavaged to release a large N-terminal fragment | |
| Cleavage Information | GPI-anchor | |
| PMID | 3380796 |
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Start | End |
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22 | 788 |
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789 | 810 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | CSQL*CVNL | 367 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | VTEN*IQWP | 559 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | No_information | (unknown) | 3380796 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Urine | 15529407 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |