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| UniProt ID |
P00533 |
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| Entry Name |
EGFR_HUMAN |
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| Protein Name |
Epidermal growth factor receptor |
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| Primary Gene Name |
EGFR |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Tyrosine-protein kinase |
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| Membrane Location |
Secreted |
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| Substrate Name | EGFR | |
| Cell Type | ||
| Substrate Description | receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cancer (urothelial bladder cancer) | |
| Short Summary of Papers | shed soluble EGFR ectodomain is detected in bladder cancer cell and urine in some patients with high-grade bladder cancer, may serve as prognostic biomarkers of bladder cancer. | |
| Cleavage Information | NONE | |
| PMID | 25719831 23731208 |
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Start | End |
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25 | 645 |
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646 | 668 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ASRA*LEEK | 24 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| MEROPS | ATNI*KHFK | 356 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | RRLL*QERE | 683 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | RRLL*QERE | 683 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| MEROPS | LWIP*EGEK | 733 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | LWIP*EGEK | 733 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| MEROPS | DEED*MDDV | 1006 | caspase-3 | physiologically relevant | NONE | 11226410 | ||
| MEROPS | DMDD*VVDA | 1009 | caspase-3 | physiologically relevant | NONE | 11226410 | ||
| MEROPS | PSTS*RTPL | 1030 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | PSTS*RTPL | 1030 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| MEROPS | QSCP*IKED | 1059 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | QSCP*IKED | 1059 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| MEROPS | DDTF*LPVP | 1086 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | DDTF*LPVP | 1086 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| MEROPS | NSTF*DSPA | 1151 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| MEROPS | KPNG*IFKG | 1185 | calpain-2 | physiologically relevant | NONE | 8055914 | ||
| PMAP | KPNG*IFKG | 1185 | calpain-2 | This entry is based on an experiment | N-terminal sequencing | 8055914 | ||
| PAPER | No_information | metalloproteinase | 25719831 23731208 | |||||
| PMAP | No_information | caspase-3 | This entry is based on an experiment | 11226410 | ||||
| PMAP | No_information | caspase-1 | This entry is based on an experiment | 11226410 | ||||
| PMAP | No_information | caspase-7 | This entry is based on an experiment | 11226410 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |