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| UniProt ID |
O95980 |
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| Entry Name |
RECK_HUMAN |
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| Protein Name |
Reversion-inducing cysteine-rich protein with Kazal motifs |
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| Primary Gene Name |
RECK |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Serine protease inhibitor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | reversion-inducing cysteine-rich protein with Kazal motifs(RECK) | |
| Cell Type | ||
| Substrate Description | negatively regulates matrix metalloproteinase-9 (MMP-9). may also regulate MMP-2 and MT1-MMP | |
| Substrate Function Category | enzyme Inhinitor | |
| Substrate Function Subtype | ||
| Sheddase | MMP2, MMP7 | |
| Shedding-related Disease | peptidase inhibitor | |
| Short Summary of Papers | RECK is cleaved by MMP-2 and MMP-7 and competitively inhibits MMP-7-catalyzed cleavage of fibronectin, demonstrating that RECK could protect fibronectin from MMP-mediated degradation. | |
| Cleavage Information | GPI-anchor | |
| PMID | 19022775 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | EVAG*GLAP | 26 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | EVAG*GLAP | 26 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | FRSC*NAQS | 370 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | FDKE*KLDT | 839 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | TIAK*VTNK | 846 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | No_information | MMP2,MMP7 | 19022775 | |||||