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| UniProt ID |
O95274 |
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| Entry Name |
LYPD3_HUMAN |
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| Protein Name |
Ly6/PLAUR domain-containing protein 3 |
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| Primary Gene Name |
LYPD3 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | PLAUR domain-containing protein 3 (C4.4A) | |
| Cell Type | ||
| Substrate Description | cell migration, urothelial cell-matrix interactions. tumor progression | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cancer | |
| Short Summary of Papers | cleavage of C4.4A by ADAM10 and ADAM17 promote release from the plasma membrane and the cleavage may contributes to tumor progression. | |
| Cleavage Information | GPI-anchor | |
| PMID | 18979631 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | NKTY*FSPR | 230 | Chymotrypsinogen A | 15012588 | ||||
| HPRD | KTYF*SPRI | 231 | Chymotrypsinogen A | 15012588 | ||||
| HPRD | FSPR*IPPL | 234 | Trypsin 1 | 15012588 | ||||
| PAPER | Y---R | ADAM10,ADAM17 | 18979631 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |