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| UniProt ID |
O95150 |
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| Entry Name |
TNF15_HUMAN |
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| Protein Name |
Tumor necrosis factor ligand superfamily member 15 |
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| Primary Gene Name |
TNFSF15 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | TL1A(LIFRĪ±) | |
| Cell Type | ||
| Substrate Description | receptor for TNFRSF25 and TNFRSF6B. mediates activation of NF-kappa-B. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | RNF41 (ring finger protein 41) degradation and ectodomain shedding of cytokine receptor, and mediate the increased soluble LIFRĪ± level shed by metalloprotease.;TL1A is involved in the regulation of endothelial cell senescence, via a novel fragment produced by differential ectodomain shedding. | |
| Cleavage Information | NONE | |
| PMID | 21378310 20675618 |
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Start | End |
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36 | 56 |
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57 | 251 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | QFQA*LKGQ | 71 | 11911831 | |||||
| PAPER | SHQQ*VYAP | 83 | metalloprotease | 21378310 20675618 | ||||