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| UniProt ID |
O94985 |
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| Entry Name |
CSTN1_HUMAN |
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| Protein Name |
Calsyntenin-1 |
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| Primary Gene Name |
CLSTN1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Postsynaptic cell membrane |
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| Substrate Name | Calsyntenin-1(Alc-alpha) | |
| Cell Type | ||
| Substrate Description | cargo-receptor for the kinesin-1 motor that mediates anterograde transport of APP; may modulate Ca+2-mediated postsynaptic signals. | |
| Substrate Function Category | disease;central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | Alzheimer Disease;cell surface protein | |
| Short Summary of Papers | small Peptides p3-Alcs were generated via the cleavage of Alcadeins were cleavages by ADAM10/17 and γ-Secretases(regulated intramembrane proteolysis) ; calsyntenin-1 undergoes proteolytically cleaved, and calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca+2 signaling.equentially. the alterations of C termini of p3-Alcs may indicate Alzheimer Disease-related γ-Secretase Dysfunction | |
| Cleavage Information | NONE | |
| PMID | 19864413 11161476 |
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Start | End |
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29 | 859 |
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860 | 880 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GVWA*ARVN | 28 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15037614 | ||
| MEROPS | TVLL*DPPL | 55 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | TVLL*DPPL | 55 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | NVPF*DAVV | 96 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | NVPF*DAVV | 96 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| ASCENT | ASVQ*ATVE | 300 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ASVQ*ATVE | 300 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PMAP | No_information | NONE | This entry is based on an experiment | 11161476 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(metastatic non-small-cell lung cancer) | 24667143 | |
| HCSD | cancer(lung cancer) | 21186846 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||