UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O94898
Entry Name

LRIG2_HUMAN
Protein Name

Leucine-rich repeats and immunoglobulin-like domains protein 2
Primary Gene Name

LRIG2
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name LRIG2
Cell Type glioblastoma cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase BACE1
Shedding-related Disease
Short Summary of Papers Soluble LRIG2 ectodomain is released from glioblastoma cells, which promotes proliferation and inhibits the apoptosis of glioblastoma cells.
Cleavage Information
PMID 20041192 25353163



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		41 807
Transmembrane
 		808 828



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER PAAG*AGLC 39 UNKNOWN Mass spectrometry 33796845   
ASCENT AAGA*GLCP 40 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AAGA*GLCP 40 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AAGA*GLCP 40 UNKNOWN subtiligase-based N-terminal sequencing
MEROPS AAGA*GLCP 40 unknown peptidase physiologically relevant Mass spectroscopy 26796116   
PAPER AAGA*GLCP 40 UNKNOWN Mass spectrometry 33796845   
ASCENT ANAS*LTVL 689 UNKNOWN subtiligase-based N-terminal sequencing 33536314   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(23 cancer cell lines) 20124221