UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O75596
Entry Name

CLC3A_HUMAN
Protein Name

C-type lectin domain family 3 member A
Primary Gene Name

CLEC3A
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted



Biological Literature Report of Shedding
Substrate Name C-type lectin domain family 3 member A (CLEC3A)
Cell Type
Substrate Description promotes cell adhesion to laminin-332 and fibronectin.
Substrate Function Category cell surface structure
Substrate Function Subtype
Sheddase MMP7
Shedding-related Disease proteoglycan
Short Summary of Papers CLEC3A binds to heparan sulfate proteoglycans on cell surface, leading to the enhancement of cell adhesion to integrin ligands on ECM, cleavage of CLEC3A by MMP-7 weakens the stable adhesion of tumor cells to the matrix and promotes their migration in tumor microenvironments.
Cleavage Information NONE
PMID 19173304



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER EVNA*LKEI 57 MMP7 19173304   
PAPER EIQA*LQTC 63 MMP7 19173304   
PAPER AISF*LNWD 151 MMP7 19173304   
MEROPS QTTS*HTSR unknown peptidase physiologically relevant Mass spectroscopy 26796116   
MEROPS EVNA*LKEI matrix metallopeptidase-7 physiologically relevant N-terminal sequencing 19173304   
MEROPS EIQA*LQTV matrix metallopeptidase-7 physiologically relevant N-terminal sequencing 19173304   
MEROPS AISF*LNWD matrix metallopeptidase-7 physiologically relevant N-terminal sequencing 19173304   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA