UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O75581
Entry Name

LRP6_HUMAN
Protein Name

Low-density lipoprotein receptor-related protein 6
Primary Gene Name

LRP6
Organism

Homo sapiens (Human)
Molecular Function

Developmental protein
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name low-density lipoprotein receptor-related protein 6 (LRP6)
Cell Type
Substrate Description cell-surface coreceptor of Wnt/beta-catenin signaling. component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling.
Substrate Function Category lipid (lipoprotein receptor famiy)
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor
Short Summary of Papers LRP6 undergoes ectodomain shedding and the following RIP (regulated intramembrane proteolysis) by secretase, the intracellular domain (ICD) then binds to GSK3 and activates the canonical Wnt signaling pathway.
Cleavage Information NONE
PMID 17326769



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 1370
Transmembrane
 		1371 1393



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS EFNK*TESV 82 lysyl endopeptidase (bacteria) not physiologically relevant NONE NONE   
MEROPS LGEK*LYWT 108 lysyl endopeptidase (bacteria) not physiologically relevant NONE NONE   
PAPER No_information metalloproteinase 17326769   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD cancer(non small cell lung cancer) 19655816