UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O75509
Entry Name

TNR21_HUMAN
Protein Name

Tumor necrosis factor receptor superfamily member 21
Primary Gene Name

TNFRSF21
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Death Receptor 6
Cell Type
Substrate Description T cell activation, immune regulation, apoptosis
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; receptor (Death Receptor)
Sheddase MTMMP1
Shedding-related Disease cell receptor
Short Summary of Papers (hypothesis) MT1-MMP proteolysis of the ectodomain might regulate death receptor-6 signaling and apoptosis.
Cleavage Information NONE
PMID 15118097



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		42 349
Transmembrane
 		350 370



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information MTMMP1 Mass spectroscopy 15118097   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Cerebrospinal fluid 15582749
HCSD cancer(prostate cancer) 22908226
HCSD cancer(colorectal cancer 24418523
HCSD cancer(breast cancer) 24505115
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137