UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O75326
Entry Name

SEM7A_HUMAN
Protein Name

Semaphorin-7A
Primary Gene Name

SEMA7A
Organism

Homo sapiens (Human)
Molecular Function

Developmental protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Semaphorin 7A
Cell Type human platelet
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease
Short Summary of Papers Cleavage of semaphorin 7A is associated with α-granules; the cleavage was reduced by an inhibitor of ADAM17.
Cleavage Information
PMID 20962327



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS AASA*QGHL 44 unknown peptidase physiologically relevant Mass spectroscopy 26796116   
MEROPS CALA*ASLW 648 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327
SPD 22728825
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Plasma/Serum 16878292
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(non small cell lung cancer) 19655816