UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O75056
Entry Name

SDC3_HUMAN
Protein Name

Syndecan-3
Primary Gene Name

SDC3
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Syndecan-3
Cell Type
Substrate Description cell surface proteoglycan that may bear heparan sulfate. organization of cell shape by affecting the actin cytoskeleton
Substrate Function Category cell surface structure
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease proteoglycan
Short Summary of Papers metalloproteinase-dependent shedding of syndecan-3 may modulate the biological function of this proteoglycan. syndecan-3 is subject to RIP (regulated intramembrane proteolysis) by presenilin/gamma-secretase following ectodomain shedding
Cleavage Information NONE
PMID 12929127 14504279



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		1 387
Transmembrane
 		388 408



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT AAAK*ASSP 342 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER GSSA*AQLP 371 UNKNOWN Mass spectrometry 33796845   
PAPER AQLP*QKSI 375 UNKNOWN Mass spectrometry 33796845   
HPRD AAFL*VTLL 403 14504279   
MEROPS AAFL*VTLL 403 presenilin 1 physiologically relevant NONE 14504279   
HPRD AFLV*TLLI 404 14504279   
MEROPS AFLV*TLLI 404 presenilin 1 physiologically relevant NONE 14504279   
MEROPS FLVT*LLIY 405 presenilin 1 physiologically relevant NONE 14504279   
MEROPS LVTL*LIYR 406 presenilin 1 physiologically relevant NONE 14504279   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825