UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O60603
Entry Name

TLR2_HUMAN
Protein Name

Toll-like receptor 2
Primary Gene Name

TLR2
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Toll-like receptor 2(TLR2)
Cell Type
Substrate Description innate immune response. immune response against pathogens through recognition of molecular patterns specific to microorganisms.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers soluble TLR2 ectodomain generated by metalloproteinase inhibits TLR2-induced cytokine production, TLR2-shedding product might be a functional negative regulator of the receptor pathway
Cleavage Information NONE
PMID 25531754



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 588
Transmembrane
 		589 609



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM10,ADAM17 25531754   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692