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|---|---|---|
| UniProt ID |
O60500 |
|
| Entry Name |
NPHN_HUMAN |
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| Protein Name |
Nephrin |
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| Primary Gene Name |
NPHS1 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
|
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | nephrin | |
| Cell Type | ||
| Substrate Description | development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. | |
| Substrate Function Category | disease;renal | |
| Substrate Function Subtype | ||
| Sheddase | serine protease | |
| Shedding-related Disease | preeclampsia | |
| Short Summary of Papers | preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. | |
| Cleavage Information | NONE | |
| PMID | 18287402 |
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|---|---|---|
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Start | End |
|
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23 | 1055 |
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1056 | 1076 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | serine protease | 18287402 | |||||