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| UniProt ID |
O60462 |
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| Entry Name |
NRP2_HUMAN |
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| Protein Name |
Neuropilin-2 |
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| Primary Gene Name |
NRP2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Secreted |
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| Substrate Name | neuropilin-2 | |
| Cell Type | ||
| Substrate Description | receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | rheumatoid arthritis | |
| Short Summary of Papers | soluble neuropilin-2 has no antirepellent activity but aggravates sympathetic nerve fiber repulsion and arthritis. Increased shedding of neuropilin-2 is probably an unfavorable sign in RA. | |
| Cleavage Information | NONE | |
| PMID | 19790074 |
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Start | End |
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21 | 864 |
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865 | 889 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | EGDC*KYDW | 208 | peptidyl-Lys metallopeptidase | not physiologically relevant | NONE | NONE | ||
| MEROPS | MAVA*KDGFS | 256 | peptidyl-Lys metallopeptidase | not physiologically relevant | NONE | NONE | ||
| PAPER | PISA*FAGE | 806 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ISAF*AGEN | 807 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unknown) | 19790074 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |