UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O54942
Entry Name

CLD5_MOUSE
Protein Name

Claudin-5
Primary Gene Name

Cldn5
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name claudin-5
Cell Type mouse brain microvascular endothelial cell line, bEnd.3 (American Type Culture Collection)
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM12, ADAM17
Shedding-related Disease
Short Summary of Papers ADAM12 and ADAM17 are responsible for the disappearance of claudin-5 from cell membranes of neural vascular barrier under hypoxia.
Cleavage Information
PMID 26242473



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		8 28
Extracellular
 		29 81
Transmembrane
 		82 102
Transmembrane
 		124 144
Extracellular
 		145 160
Transmembrane
 		161 181



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA