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| UniProt ID |
O43278 |
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| Entry Name |
SPIT1_HUMAN |
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| Protein Name |
Kunitz-type protease inhibitor 1 |
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| Primary Gene Name |
SPINT1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Serine protease inhibitor |
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| Membrane Location |
Secreted |
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| Substrate Name | Hepatocyte growth factor activator inhibitor type 1 (HAI-1) | |
| Cell Type | ||
| Substrate Description | inhibitor of HGF activator. | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | growth factor (HGF) | |
| Short Summary of Papers | proteolytic cleavage to eelease aoluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. | |
| Cleavage Information | NONE | |
| PMID | 10544273 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GTQA*GPPP | 35 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| MEROPS | MERR*HPVC | 327 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | QRIH*FPSD | 383 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | QRIH*FPSD | 383 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | No_information | metalloprotease | 10544273 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |