UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O43157
Entry Name

PLXB1_HUMAN
Protein Name

Plexin-B1
Primary Gene Name

PLXNB1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name PLXNB1
Cell Type Human HepG2, 293T, HT-29, SW-48 cells, canine kidney MDCK, murine NIH-3T3 cell lines, human GTL-16 gastric carcinoma cell line and the Suit2 pancreatic cell line
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase subtilisin-like proprotein convertases
Shedding-related Disease
Short Summary of Papers plexin-B1 and plexin-B2 are proteolytically cleaved; the processing events significantly increase their ligand binding and functional response
Cleavage Information
PMID 12533544



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 1490
Transmembrane
 		1491 1511



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS WVLT*LQPL 19 unknown peptidase physiologically relevant Mass spectroscopy 26796116   
MEROPS RRRR*VVPE 1305 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16083276
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
locate 17986452