UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O35930
Entry Name

GP1BA_MOUSE
Protein Name

Platelet glycoprotein Ib alpha chain
Primary Gene Name

Gp1ba
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name GPIbα
Cell Type platelet
Substrate Description
Substrate Function Category disease
Substrate Function Subtype Disease: thrombus formation regulation
Sheddase ADAM17
Shedding-related Disease thrombus formation
Short Summary of Papers shear-induced interaction of platelets with immobilized VWF results in GPIbα ectodomain shedding
Cleavage Information NONE
PMID 19820200
Substrate Name GPIbα
Cell Type platelet
Substrate Description platelet hemostasis
Substrate Function Category blood and homoeostasis
Substrate Function Subtype platelet; platelet glycoprotein
Sheddase ADAM17
Shedding-related Disease platelet (cell surface protein)
Short Summary of Papers releases glycocalicin to the plasma, mediate clearance of stored platelets
Cleavage Information NONE
PMID 24119228



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		17 612
Transmembrane
 		613 633



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 NONE Gel electrophoresis 16179345   
PMAP No_information ADAM17 peptidase This_entry_is_based_on_an_experiment. Others 15345652   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825