UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O35598
Entry Name

ADA10_MOUSE
Protein Name

Disintegrin and metalloproteinase domain-containing protein 10
Primary Gene Name

Adam10
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protease
Metalloprotease
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name ADAM10
Cell Type
Substrate Description diverse cellular process regulated by proteolytic cleavage
Substrate Function Category enzyme
Substrate Function Subtype enzyme (protease)
Sheddase ADAM9, ADAM10
Shedding-related Disease protease (metalloproteinase)
Short Summary of Papers (autolytic) processing of ADAM10 for proteolytic activity
Cleavage Information NONE
PMID 26554003
Substrate Name ADAM28
Cell Type
Substrate Description diverse cellular process regulated by proteolytic cleavage
Substrate Function Category enzyme
Substrate Function Subtype enzyme (protease)
Sheddase ADAM28
Shedding-related Disease protease (metalloproteinase)
Short Summary of Papers autolytic processing of ADAM28 for proteolytic activity
Cleavage Information NONE
PMID 15013428 26554003 23643150



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 673
Transmembrane
 		674 694



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM9 NONE NONE 26554003   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825