UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O35516
Entry Name

NOTC2_MOUSE
Protein Name

Neurogenic locus notch homolog protein 2
Primary Gene Name

Notch2
Organism

Mus musculus (Mouse)
Molecular Function

Activator
Developmental protein
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Notch2
Cell Type
Substrate Description cell fate and development
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; receptor
Sheddase ADAM10
Shedding-related Disease cell receptor
Short Summary of Papers ectodomain shedding result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes
Cleavage Information NONE
PMID 10958687 24842903



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 1679
Transmembrane
 		1680 1700



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unkown) 10958687   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA