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| UniProt ID |
O35305 |
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| Entry Name |
TNR11_MOUSE |
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| Protein Name |
Tumor necrosis factor receptor superfamily member 11A |
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| Primary Gene Name |
Tnfrsf11a |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | receptor activator of NF-kappaB (RANK) | |
| Cell Type | ||
| Substrate Description | receptor for TNFSF11/RANKL/TRANCE/OPGL. involved in the regulation of interactions between T-cells and dendritic cells. essential for RANKL-mediated osteoclastogenesis. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | RANK ligand induces ectodomain shedding of and the release of soluble form RANK. ectodomain shedding may be involved in the regulation of RANK functions. | |
| Cleavage Information | ZNo-Human: | |
| PMID | 20118276 |
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Start | End |
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31 | 214 |
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215 | 234 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | M*T | 199 | metalloprotease | synthesized peptide | 20118276 | |||
| PAPER | T*L | 200 | metalloprotease | synthesized peptide | 20118276 | |||
| PAPER | No_information | metalloprotease | 20118276 | |||||