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| UniProt ID |
O35235 |
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| Entry Name |
TNF11_MOUSE |
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| Protein Name |
Tumor necrosis factor ligand superfamily member 11 |
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| Primary Gene Name |
Tnfsf11 |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | TRANCE, RANKL, OPGL, ODF | |
| Cell Type | human kidney cell line 293T, mouse bone marrow stromal cell line TM8B2, T cell hybridoma KMLS-8.3.5.1 | |
| Substrate Description | immune response (NF-κB signalling) | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | RANKL shedding mediate regulation of osteoclastogenesis | |
| Cleavage Information | NONE | |
| PMID | 10224132 17018528 |
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Start | End |
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49 | 69 |
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70 | 316 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | IVGP*QRFS | 136 | ADAM17,ADAM19,ADAM33 | 16542157 | ||||
| MEROPS | GPQR*FSGA | 138 | ADAM19 peptidase | not physiologically relevant | NONE | 12682046 | ||
| MEROPS | GPQR*FSGA | 138 | ADAM10 peptidase | physiologically relevant | N-terminal sequencing | 17018528 | ||
| MEROPS | APAM*MEGS | 145 | membrane-type matrix metallopeptidase-1 | physiologically relevant | N-terminal sequencing | 17018528 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||