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| UniProt ID |
O35188 |
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| Entry Name |
X3CL1_MOUSE |
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| Protein Name |
Fractalkine |
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| Primary Gene Name |
Cx3cl1 |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | Fractalkine (CX3CL1) | |
| Cell Type | endothelial cell | |
| Substrate Description | Leukocyte Recruitment - Chemokine recruitment of leukocytes,Firm adhesion and locomotion to the endothelial cell junction | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM17, ADAM10 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | neuroprotective, soluble chemoattractant, decreased endothelial adhesiveness, de-adhesion of bound leukocytes | |
| Cleavage Information | NONE | |
| PMID | 16565325 11495925 18951988 |
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Start | End |
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25 | 336 |
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337 | 357 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | QHLG*MTKC | 28 | matrix metallopeptidase-2 | physiologically relevant | NONE | 17200105 | ||
| MEROPS | QAAA*LTKN | 95 | matrix metallopeptidase-2 | physiologically relevant | NONE | 17200105 | ||
| PAPER | ATRR*QAVG | 338 | ADAM17 | NONE | 16542157 | |||
| PaperC | No_information | BACE1 | Type I | proteomics | 22728825 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||