UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O15393
Entry Name

TMPS2_HUMAN
Protein Name

Transmembrane protease serine 2
Primary Gene Name

TMPRSS2
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Transmembrane serine protease 2
Cell Type
Substrate Description serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions
Substrate Function Category disease
Substrate Function Subtype
Sheddase Transmembrane serine protease 2
Shedding-related Disease cancer (prostate cancer)
Short Summary of Papers autocatalytic cleavage of TMPRSS2 results in the secretion of the protease, highly expressed in prostate cancer
Cleavage Information NONE
PMID 11245484



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		85 105
Extracellular
 		106 492



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD RQSR*IVGG 255 Transmembrane serine protease 2 11245484   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Urine 16948836
HCSD cancer(Liver metastasis in colorectal cancer) 23443137