UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O15354
Entry Name

GPR37_HUMAN
Protein Name

Prosaposin receptor GPR37
Primary Gene Name

GPR37
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Prosaposin receptor GPR37
Cell Type
Substrate Description G protein-coupled receptor. receptor for the neuroprotective and glioprotective factor prosaposin.
Substrate Function Category disease
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease Parkinson's disease
Short Summary of Papers the shedding process of GPR37 is suggested to be related to natural physiological role of the receptor and may be used to assess GPR37 function and role in PD and other nervous system disorders.
Cleavage Information NONE
PMID 26869225



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		27 265
Transmembrane
 		266 286
Transmembrane
 		300 320
Extracellular
 		321 335
Transmembrane
 		336 356
Transmembrane
 		380 400
Extracellular
 		401 443
Transmembrane
 		444 464
Transmembrane
 		494 514
Extracellular
 		515 531
Transmembrane
 		532 552



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER RSQE*QSVK 167 metalloproteinase 26869225   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Bronchoalveolar lavage fluid 16497942
HCSD cancer (lung cancer) 19776420