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| UniProt ID |
O15031 |
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| Entry Name |
PLXB2_HUMAN |
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| Protein Name |
Plexin-B2 |
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| Primary Gene Name |
PLXNB2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | plexin-B2 | |
| Cell Type | Human HepG2, 293T, HT-29, SW-48 cells, canine kidney MDCK, murine NIH-3T3 cell lines, human GTL-16 gastric carcinoma cell line and the Suit2 pancreatic cell line | |
| Substrate Description | ||
| Substrate Function Category | ||
| Substrate Function Subtype | ||
| Sheddase | subtilisin-like proprotein convertases | |
| Shedding-related Disease | ||
| Short Summary of Papers | plexin-B1 and plexin-B2 are proteolytically cleaved; the processing events significantly increase their ligand binding and functional response | |
| Cleavage Information | ||
| PMID | 12533544 |
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Start | End |
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20 | 1197 |
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1198 | 1218 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AGAS*LRPR | 19 | unknown peptidase | physiologically relevant | Mass spectroscopy | 26796116 | ||
| ASCENT | ITIL*GSNL | 824 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | RQKR*DTTH | 1164 | unknown peptidase | physiologically relevant | Mass spectroscopy | 26796116 | ||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |