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|---|---|---|
| UniProt ID |
O14944 |
|
| Entry Name |
EREG_HUMAN |
|
| Protein Name |
Proepiregulin [Cleaved into: Epiregulin |
|
| Primary Gene Name |
EREG |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Mitogen |
|
| Membrane Location |
Secreted |
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|---|
| Substrate Name | epiregulin (EREG) | |
| Cell Type | ||
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | release ectodomain (soluble EGFR-ligands) to activate EGFR signaling | |
| Cleavage Information | NONE | |
| PMID | 19049889 18951988 |
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Start | End |
|
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60 | 119 |
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120 | 140 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RVAQ*VSIT | 62 | ADAM17 peptidase | not physiologically relevant | NONE | 11823465 | ||
| MEROPS | HFFL*TVHQ | 108 | ADAM17 peptidase | not physiologically relevant | NONE | 11823465 | ||