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| UniProt ID |
O14836 |
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| Entry Name |
TR13B_HUMAN |
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| Protein Name |
Tumor necrosis factor receptor superfamily member 13B |
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| Primary Gene Name |
TNFRSF13B |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | TACI | |
| Cell Type | ||
| Substrate Description | receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. involved in the stimulation of B- and T-cell function and the regulation of humoral immunity | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | TACI is sequentially processed by a disintegrin and metalloproteinase 10 and γ-secretase (RIP,regulated intramembrane proteolysis).the shed ectodomain functioned as a decoy receptor inhibiting BAFF-and APRIL-mediated B cell survival and NF-κB activation. | |
| Cleavage Information | NONE | |
| PMID | 25505277 |
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Start | End |
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1 | 165 |
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166 | 186 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | PGLK*LSAD | 154 | ADAM10 | N-terminal sequencing | 25505277 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |