|
|
||
|---|---|---|
| UniProt ID |
O14788 |
|
| Entry Name |
TNF11_HUMAN |
|
| Protein Name |
Tumor necrosis factor ligand superfamily member 11 |
|
| Primary Gene Name |
TNFSF11 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Cytokine |
|
| Membrane Location |
Secreted |
|
|
|
|---|
| Substrate Name | TRANCE, RANKL, OPGL, ODF | |
| Cell Type | human kidney cell line 293T, mouse bone marrow stromal cell line TM8B2, T cell hybridoma KMLS-8.3.5.1 | |
| Substrate Description | immune response (NF-κB signalling) | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | RANKL shedding mediate regulation of osteoclastogenesis | |
| Cleavage Information | NONE | |
| PMID | 10224132 17018528 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
48 | 68 |
|
|
69 | 317 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GSQH*IRAE | 139 | ADAM33 peptidase | physiologically relevant | NONE | 14676211 | ||
| PMAP | GSQH*IRAE | 139 | ADAM33 peptidase | This entry is based on an experiment | N-terminal sequencing | 11278735 14676211 | ||
| PMAP | GSQH*IRAE | 139 | ADAM33 peptidase | This entry is based on an experiment | N-terminal sequencing | 11278735 14676211 | ||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |