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|---|---|---|
| UniProt ID |
O14672 |
|
| Entry Name |
ADA10_HUMAN |
|
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 10 |
|
| Primary Gene Name |
ADAM10 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Cell membrane |
|
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| Substrate Name | ADAM10 | |
| Cell Type | ||
| Substrate Description | diverse cellular process regulated by proteolytic cleavage | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | enzyme (protease) | |
| Sheddase | ADAM9, ADAM10 | |
| Shedding-related Disease | protease (metalloproteinase) | |
| Short Summary of Papers | (autolytic) processing of ADAM10 for proteolytic activity | |
| Cleavage Information | NONE | |
| PMID | 26554003 |
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|---|---|---|
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Start | End |
|
|
20 | 672 |
|
|
673 | 693 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | AGMG*GQYG | 18 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | AGMG*GQYG | 18 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | HIYG*EEGS | 109 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | PELL*RKKR | 209 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | RKKR*TTSA | 213 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*TTSA | 213 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*TTSA | 213 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*TTSA | 213 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*TTSA | 213 | furin | physiologically relevant | NONE | 11481247 | ||
| MEROPS | RKKR*TTSA | 213 | PCSK7 peptidase | physiologically relevant | NONE | 11481247 | ||
| ASCENT | LGLA*WVGA | 331 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | HFSG*RTIT | 621 | ADAM10 | NONE | NONE | 26554003 | ||
| PAPER | MRCR*LVDA | 646 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GPLA*RLKK | 655 | UNKNOWN | Mass spectrometry | 33796845 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |