UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O14514
Entry Name

AGRB1_HUMAN
Protein Name

Adhesion G protein-coupled receptor B1
Primary Gene Name

ADGRB1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Brain-specific angiogenesis inhibitor 1(BAI1)
Cell Type
Substrate Description G protein-coupled receptor, angiogenesis regulation
Substrate Function Category angiogenesis
Substrate Function Subtype
Sheddase MMP14
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers the shed N-terminal fragment of BAI1 could inhibits angiogenesis (with anti-angiogenic activity)
Cleavage Information NONE
PMID 22330140



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		31 948
Transmembrane
 		949 969
Transmembrane
 		981 1001
Extracellular
 		1002 1008
Transmembrane
 		1009 1029
Transmembrane
 		1053 1073
Extracellular
 		1074 1093
Transmembrane
 		1094 1114
Transmembrane
 		1137 1157
Extracellular
 		1158 1166
Transmembrane
 		1167 1187



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER RSQS*LRS 326 MMP14 22330140   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Plasma/Serum 15822942
locate 17986452