UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

O14511
Entry Name

NRG2_HUMAN
Protein Name

Pro-neuregulin-2, membrane-bound isoform
Primary Gene Name

NRG2
Organism

Homo sapiens (Human)
Molecular Function

Growth factor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name neuregulin-2
Cell Type
Substrate Description ligand for ERBB3 and ERBB4 tyrosine kinase receptors. ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease growth factor (ERBBs)
Short Summary of Papers shedding of the NRG2 extracellular domain invovled in the reciprocal signaling between ErbB4 and NMDA receptors
Cleavage Information NONE
PMID 26027736



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		112 405
Transmembrane
 		406 426



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 26027736   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692