UniProt Summary
UniProt ID

O00559

Entry Name

RCAS1_HUMAN

Protein Name

Receptor-binding cancer antigen expressed on SiSo cells

Primary Gene Name

EBAG9

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name RCAS1
Cell Type
Substrate Description suppression of cell proliferation, induces apoptotic cell death
Substrate Function Category disease
Substrate Function Subtype
Sheddase ADAM9
Shedding-related Disease cancer
Short Summary of Papers shedding is pivotal for induction of apoptosis by RCAS1, and shed RCAS1 in the serum may be a useful biomarker for human cancer
Cleavage Information NONE
PMID 25177692



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
1 6
Transmembrane
7 27



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM9 11309369   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 15529407
HCSD cancer(ovarian cancer) 23805888