UniProt Summary
UniProt ID

O00461

Entry Name

GOLI4_HUMAN

Protein Name

Golgi integral membrane protein 4

Primary Gene Name

GOLIM4

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name Golgi integral membrane protein 4
Cell Type HeLa (ATCC); human embryonic kidney (HEK) 293-FT (Invitrogen)
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase BACE1
Shedding-related Disease
Short Summary of Papers GOLIM4 is a protein shed by BACE1.
Cleavage Information
PMID 20041192



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Transmembrane
13 33



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS M*GNGM 1 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18795103
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(Liver metastasis in colorectal cancer) 23443137